Publications of Prof. Stemmann
Article in a journal (peer-reviewed)
Hellmuth, Susanne; Stemmann, Olaf
Requirement of Nek2a and cyclin A2 for Wapl-dependent removal of cohesin from prophase chr ...
in The EMBO Journal vol. 43 (2024) . - pp. 5237-5259
doi:10.1038/s44318-024-00228-9 ...
Abdel-Salam, Ghada M. H.; Hellmuth, Susanne; Gradhand, Elise; Käseberg, Stephan; Winter, Jennifer; Pabst, Ann-Sophie; Eid, Maha M.; Thiele, Holger; Nürnberg, Peter; Budde, Birgit S.; Toliat, Mohammad Reza; Brecht, Ines B.; Schroeder, Christopher; Gschwind, Axel; Ossowski, Stephan; Häuser, Friederike; Rossmann, Heidi; Abdel-Hamid, Mohamed S.; Hegazy, Ibrahim; Mohamed, Ahmed G.; Schneider, Dominik T.; Bertoli-Avella, Aida M.; Bauer, Peter; Pearring, Jillian N.; Pfundt, Rolph; Hoischen, Alexander; Gilissen, Christian; Strand, Dennis; Zechner, Ulrich; Tashkandi, Soha A.; Faqeih, Eissa A.; Stemmann, Olaf; Strand, Susanne; Bolz, Hanno J.
Biallelic MAD2L1BP (p31ᶜᵒᵐᵉᵗ) mutation is associated with mosaic aneuploidy and juvenile g ...
in JCI Insight vol. 8 (2023) issue 22
doi:10.1172/jci.insight.170079 ...
Hellmuth, Susanne; Gómez-H., Laura; Pendás, Alberto M.; Stemmann, Olaf
Securin-independent regulation of separase by checkpoint-induced shugoshin–MAD2
in Nature vol. 580 (2020) . - pp. 536-541
doi:10.1038/s41586-020-2182-3 ...
Hellmuth, Susanne; Stemmann, Olaf
Separase-triggered apoptosis enforces minimal length of mitosis
in Nature vol. 580 (2020) . - pp. 542-547
doi:10.1038/s41586-020-2187-y ...
Henschke, Lars; Frese, Matthias; Hellmuth, Susanne; Marx, Andreas; Stemmann, Olaf; Mayer, Thomas U.
Identification of Bioactive Small Molecule Inhibitors of Separase
in ACS Chemical Biology vol. 14 (2019) issue 10. - pp. 2155-2159
doi:10.1021/acschembio.9b00661 ...
Wild, Thomas; Budzowska, Magda; Hellmuth, Susanne; Eibes, Susana; Karemore, Gopal; Barisic, Marin; Stemmann, Olaf; Choudhary, Chunaram
Deletion of APC7 or APC16 Allows Proliferation of Human Cells without the Spindle Assembly ...
in Cell Reports vol. 25 (2018) issue 9. - pp. 2317-2328
doi:10.1016/j.celrep.2018.10.104 ...
Hellmuth, Susanne; Gutiérrez-Caballero, Cristina; Llano, Elena; Pendás, Alberto M.; Stemmann, Olaf
Local activation of mammalian separase in interphase promotes double-strand break repair a ...
in The EMBO Journal vol. 37 (2018) issue 22
doi:10.15252/embj.201899184 ...
Wolf, Peter G.; Ramos, Alexander Cuba; Kenzel, Julia; Neumann, Brigitte; Stemmann, Olaf
Studying meiotic cohesin in somatic cells reveals that Rec8-containing cohesin requires St ...
in Journal of Cell Science vol. 131 (2018) issue 11
doi:10.1242/jcs.212100 ...
Ferencz, Csilla Maria; Guigas, Gernot; Veres, Andreas; Neumann, Brigitte; Stemmann, Olaf; Weiss, Matthias
In Vitro Reconstitution of the Endoplasmic Reticulum
in Current Protocols in Cell Biology vol. 76 (2017)
doi:10.1002/cpcb.30 ...
Ferencz, Csilla Maria; Guigas, Gernot; Veres, Andreas; Neumann, Brigitte; Stemmann, Olaf; Weiss, Matthias
Shaping the endoplasmic reticulum in vitro
in Biochimica et Biophysica Acta : Biomembranes vol. 1858 (2016) issue 9. - pp. 2035-2040
doi:10.1016/j.bbamem.2016.06.004 ...
Mohr, Lisa; Buheitel, Johannes; Schöckel, Laura; Karalus, Dorothea; Mayer, Bernd; Stemmann, Olaf
An Alternatively Spliced Bifunctional Localization Signal Reprograms Human Shugoshin 1 to ...
in Cell Reports vol. 12 (2015) issue 12. - pp. 2156-2168
doi:10.1016/j.celrep.2015.08.045 ...
Hellmuth, Susanne; Rata, Scott; Brown, Andreas; Heidmann, Stefan; Novak, Bela; Stemmann, Olaf
Human Chromosome Segregation Involves Multi-Layered Regulation of Separase by the Peptidyl ...
in Molecular Cell vol. 58 (2015) issue 3. - pp. 495-506
doi:10.1016/j.molcel.2015.03.025 ...
Hellmuth, Susanne; Pöhlmann, Christopher; Brown, Andreas; Böttger, Franziska; Sprinzl, Mathias; Stemmann, Olaf
Positive and Negative Regulation of Vertebrate Separase by Cdk1-Cyclin B1 May Explain Why ...
in The Journal of Biological Chemistry vol. 290 (2015) issue 12. - pp. 8002-8010
doi:10.1074/jbc.M114.615310 ...
Hellmuth, Susanne; Böttger, Franziska; Pan, Cuiping; Mann, Matthias; Stemmann, Olaf
PP2A delays APC/C-dependent degradation of separase-associated but not free securin
in The EMBO Journal vol. 33 (2014) issue 10. - pp. 1134-1147
doi:10.1002/embj.201488098 ...
Rattani, Ahmed; Wolna, Magda; Ploquin, Mickael; Helmhart, Wolfgang; Morrone, Seamus; Mayer, Bernd; Godwin, Jonathan; Xu, Wenqing; Stemmann, Olaf; Pendás, Alberto M.; Nasmyth, Kim
Sgol2 provides a regulatory platform that coordinates essential cell cycle processes durin ...
in eLife vol. 2 (2013)
doi:10.7554/eLife.01133.001 ...
Buheitel, Johannes; Stemmann, Olaf
Prophase pathway-dependent removal of cohesin from human chromosomes requires opening of t ...
in The EMBO Journal vol. 32 (2013) issue 5. - pp. 666-676
doi:10.1038/emboj.2013.7 ...
Touati, Sandra A.; Cladière, Damien; Lister, Lisa M.; Leontiou, Ioanna; Chambon, Jean-Philippe; Rattani, Ahmed; Böttger, Franziska; Stemmann, Olaf; Nasmyth, Kim; Herbert, Mary; Wassermann, Katja
Cyclin A2 Is Required for Sister Chromatid Segregation, But Not Separase Control, in Mouse ...
in Cell Reports vol. 2 (2012) issue 5. - pp. 1077-1087
doi:10.1016/j.celrep.2012.10.002 ...
Franz, André; Orth, Michael; Pirson, Paul A.; Sonneville, Remi; Blow, J. Julian; Gartner, Anton; Stemmann, Olaf; Hoppe, Thorsten
CDC-48/p97 Coordinates CDT1 Degradation with GINS Chromatin Dissociation to Ensure Faithfu ...
in Molecular Cell vol. 44 (2011) issue 1. - pp. 85-96
doi:10.1016/j.molcel.2011.08.028 ...
Schöckel, Laura; Möckel, Martin; Mayer, Bernd; Boos, Dominik; Stemmann, Olaf
Cleavage of cohesin rings coordinates the separation of centrioles and chromatids
in Nature Cell Biology vol. 13 (2011) . - pp. 966-972
doi:10.1038/ncb2280 ...
Hormanseder, Eva; Tischer, Thomas; Heubes, Simone; Stemmann, Olaf; Mayer, Thomas U.
Non-proteolytic ubiquitylation counteracts the APC/C-inhibitory function of XErp1
in EMBO Reports vol. 12 (2011) issue 5. - pp. 436-443
doi:10.1038/embor.2011.32 ...
Orth, Michael; Mayer, Bernd; Rehm, Kinga; Rothweiler, Ulli; Heidmann, Doris; Holak, Tad A.; Stemmann, Olaf
Shugoshin is a Mad1/Cdc20-like interactor of Mad2
in The EMBO Journal vol. 30 (2011) . - pp. 2868-2880
doi:10.1038/emboj.2011.187 ...
Wang, Lily Hui-Ching; Mayer, Bernd; Stemmann, Olaf; Nigg, Erich A.
Centromere DNA decatenation depends on cohesin removal and is required for mammalian cell ...
in Journal of Cell Science vol. 123 (2010) issue 5. - pp. 806-813
doi:10.1242/jcs.058255 ...
Kudo, Nobuaki R.; Anger, Martin; Peters, Antoine H.; Stemmann, Olaf; Theussl, Hans-Christian; Helmhart, Wolfgang; Kudo, Hiromi; Heyting, Christa; Nasmyth, Kim
Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meios ...
in Journal of Cell Science vol. 122 (2009) issue 15. - pp. 2686-2698
doi:10.1242/jcs.035287 ...
Daub, Henrik; Olsen, Jesper V.; Bairlein, Michaela; Gnad, Florian; Oppermann, Felix S.; Korner, Roman; Greff, Zoltán; Keri, György; Stemmann, Olaf; Mann, Matthias
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across th ...
in Molecular Cell vol. 31 (2008) issue 3. - pp. 438-448
doi:10.1016/j.molcel.2008.07.007 ...
Rothweiler, Ulli; Czarna, Anna; Weber, Lutz; Popowicz, Grzegorz M.; Brongel, Kinga; Kowalska, Kaja; Orth, Michael; Stemmann, Olaf; Holak, Tad A.
NMR screening for lead compounds using tryptophan-mutated proteins.
in Journal of Medicinal Chemistry vol. 51 (2008) issue 16. - pp. 5035-5042
doi:10.1021/jm8002813 ...
Boos, Dominik; Kuffer, Christian; Lenobel, Rene; Korner, Roman; Stemmann, Olaf
Phosphorylation-dependent binding of cyclin B1 to a Cdc6-like domain of human separase
in The Journal of Biological Chemistry vol. 283 (2008) issue 2. - pp. 816-823
doi:10.1074/jbc.M706748200 ...
Nabti, Ibtissem; Reis, Alexandra; Levasseur, Mark; Stemmann, Olaf; Jones, Keith T.
Securin and not CDK1/cyclin B1 regulates sister chromatid disjunction during meiosis II in ...
in Developmental Biology vol. 321 (2008) issue 2. - pp. 379-386
doi:10.1016/j.ydbio.2008.06.036 ...
Heubes, Simone; Stemmann, Olaf
The AAA-ATPase p97Ufd1/Npl4 Is Required for ERAD but Not for Spindle Disassembly in Xenopu ...
in Journal of Cell Science vol. 120 (2007) issue 8. - pp. 1325-1329
doi:10.1242/jcs.006924 ...
Holland, Andrew J.; Böttger, Franziska; Stemmann, Olaf; Taylor, Stephen S.
Protein phosphatase 2A and separase form a complex regulated by separase autocleavage
in The Journal of Biological Chemistry vol. 282 (2007) issue 34. - pp. 24623-24632
doi:10.1074/jbc.M702545200 ...
Gorr, Ingo H.; Reis, Alexandra; Boos, Dominik; Wühr, Martin; Madgwick, Suzanne; Jones, Keith T.; Stemmann, Olaf
Essential Cdk1-inhibitory role for separase during meiosis I in vertebrate oocytes
in Nature Cell Biology vol. 8 (2006) . - pp. 1035-1037
doi:10.1038/ncb1467 ...
Stemmann, Olaf; Boos, Dominik; Gorr, Ingo H.
Anaphase Topsy-Turvy : Cdk1 a securin, separase a CKI
in Cell Cycle vol. 5 (2006) issue 1. - pp. 11-13
doi:10.4161/cc.5.1.2296 ...
Gorr, Ingo H.; Boos, Dominik; Stemmann, Olaf
Mutual Inhibition of Separase and Cdk1 by Two-Step Complex Formation
in Molecular Cell vol. 19 (2005) issue 1. - pp. 135-141
doi:10.1016/j.molcel.2005.05.022 ...
Viadiu, Hector; Stemmann, Olaf; Kirschner, Marc W.; Walz, Thomas
Domain structure of separase and its binding to securin as determined by EM
in Nature Structural & Molecular Biology vol. 12 (2005) . - pp. 552-553
doi:10.1038/nsmb935 ...
Stemmann, Olaf; Boos, Dominik; Gorr, Ingo H.
Rephrasing anaphase : Separase FEARs shugoshin
in Chromosoma vol. 113 (2005) issue 8. - pp. 409-417
doi:10.1007/s00412-005-0331-y ...
Pfleghaar, Katrin; Heubes, Simone; Cox, Jürgen; Stemmann, Olaf; Speicher, Michael R.
Securin Is Not Required for Chromosomal Stability in Human Cells
in PLoS Biology vol. 3 (2005) issue 12
doi:10.1371/journal.pbio.0030416 ...
Gerber, Scott A.; Rusch, John; Stemmann, Olaf; Kirschner, Marc W.; Gygi, Steven P.
Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS
in Proceedings of the National Academy of Sciences of the United States of America vol. 100 (2003) issue 12. - pp. 6940-6945
doi:10.1073/pnas.0832254100 ...
Zou, Hui; Stemmann, Olaf; Anderson, Jens S.; Mann, Matthias; Kirschner, Marc W.
Anaphase specific auto-cleavage of separase
in FEBS Letters vol. 528 (2002) issue 1-3. - pp. 246-250
doi:10.1016/S0014-5793(02)03238-6 ...
Stemmann, Olaf; Neidig, Anke; Köcher, Thomas; Wilm, Matthias; Lechner, Johannes
Hsp90 enables Ctf13p/Skp1p to nucleate the budding yeast kinetochore
in Proceedings of the National Academy of Sciences of the United States of America vol. 99 (2002) issue 13. - pp. 8585-8590
doi:10.1073/pnas.082223899 ...
Stemmann, Olaf; Zou, Hui; Gerber, Scott A.; Gygi, Steven P.; Kirschner, Marc W.
Dual inhibition of sister chromatid separation at metaphase
in Cell vol. 107 (2001) issue 6. - pp. 715-726
doi:10.1016/S0092-8674(01)00603-1 ...
Pietrasanta, Lía I.; Thrower, Douglas; Hsieh, Wan; Rao, Shashirekha; Stemmann, Olaf; Lechner, Johannes; Carbon, John; Hansma, Helen
Probing the Saccharomyces cerevisiae centromeric DNA (CEN DNA)-binding factor 3 (CBF3) kin ...
in Proceedings of the National Academy of Sciences of the United States of America vol. 96 (1999) issue 7. - pp. 3757-3762
doi:10.1073/pnas.96.7.3757 ...
Ortiz, Jennifer; Stemmann, Olaf; Rank, Simone; Lechner, Johannes
A putative protein complex consisting of Ctf19, Mcm21, and Okp1 represents a missing link ...
in Genes & Development vol. 13 (1999) . - pp. 1140-1155
http://www.ncbi.nlm.nih.gov/pubmed/10323865?ordina ...
Brikun, I.; Suziedelis, K.; Stemmann, Olaf; Zhong, R.; Alikhanian, L.; Linkova, E.; Mironov, A.; Berg, D. E.
Analysis of CRP-CytR interactions at the Escherichia coli udp promoter
in Journal of Bacteriology vol. 178 (1996) issue 6. - pp. 1614-1622
http://www.ncbi.nlm.nih.gov/pubmed/8626289?ordinal ...
Stemmann, Olaf; Lechner, Johannes
The Saccharomyces cerevisiae kinetochore contains a cyclin-CDK complexing homologue, as id ...
in The EMBO Journal vol. 15 (1996) issue 14. - pp. 3611-3620
http://www.ncbi.nlm.nih.gov/pubmed/8670864?ordinal ...
Preprint, postprint, working paper, discussion paper
Hellmuth, Susanne; Stemmann, Olaf
In vitro reconstitution reveals requirement of Nek2a and cyclin A2 for Wapl-dependent remo ...
bioRxiv, 2024
doi:10.1101/2024.03.12.584565 ...