Team > Prof. Dr. Olaf Stemmann
Prof. Dr. Olaf Stemmann
Biology, Chemistry & Earth Sciences
Chair of Genetics
CV
| 1989-1995 | Biochemistry student, University of Regensburg |
| 1992-1993 | Exchange student, Washington University, Saint Louis, USA |
| 1995-1999 | Graduate student in the lab of Johannes Lechner,University of Regensburg and University of Heidelberg |
| 1997 | Visiting scientist in the lab of John Carbon, UCSB, Santa Barbara, USA |
| 2000-2002 | Postdoctoral fellow (supported by HFSP) in the lab of Marc Kirschner, Harvard Medical School, Boston, USA |
| 2002-2008 | Independent Emmy Noether group leader in the department of Stefan Jentsch, Max-Planck-Institute of Biochemistry, Martinsried |
| since 2008 | Chair of genetics, University of Bayreuth |
Publication list, citation metrics, h-index on Google Scholar | |
| ORCID |
Biology, Chemistry & Earth Sciences
Chair of Genetics
Publications
2024
Hellmuth, Susanne; Stemmann, Olaf
In vitro reconstitution reveals requirement of Nek2a and cyclin A2 for Wapl-dependent removal o ...
bioRxiv, 2024
doi:10.1101/2024.03.12.584565 ...
Hellmuth, Susanne; Stemmann, Olaf
Requirement of Nek2a and cyclin A2 for Wapl-dependent removal of cohesin from prophase chromati ...
in The EMBO Journal volume 43 (2024) . - page 5237-5259
doi:10.1038/s44318-024-00228-9 ...
2023
Abdel-Salam, Ghada M. H.; Hellmuth, Susanne; Gradhand, Elise; Käseberg, Stephan; Winter, Jennifer; Pabst, Ann-Sophie; Eid, Maha M.; Thiele, Holger; Nürnberg, Peter; Budde, Birgit S.; Toliat, Mohammad Reza; Brecht, Ines B.; Schroeder, Christopher; Gschwind, Axel; Ossowski, Stephan; Häuser, Friederike; Rossmann, Heidi; Abdel-Hamid, Mohamed S.; Hegazy, Ibrahim; Mohamed, Ahmed G.; Schneider, Dominik T.; Bertoli-Avella, Aida M.; Bauer, Peter; Pearring, Jillian N.; Pfundt, Rolph; Hoischen, Alexander; Gilissen, Christian; Strand, Dennis; Zechner, Ulrich; Tashkandi, Soha A.; Faqeih, Eissa A.; Stemmann, Olaf; Strand, Susanne; Bolz, Hanno J.
Biallelic MAD2L1BP (p31ᶜᵒᵐᵉᵗ) mutation is associated with mosaic aneuploidy and juvenile granul ...
in JCI Insight volume 8 (2023) issue 22
doi:10.1172/jci.insight.170079 ...
2020
Hellmuth, Susanne; Gómez-H., Laura; Pendás, Alberto M.; Stemmann, Olaf
Securin-independent regulation of separase by checkpoint-induced shugoshin–MAD2
in Nature volume 580 (2020) . - page 536-541
doi:10.1038/s41586-020-2182-3 ...
Hellmuth, Susanne; Stemmann, Olaf
Separase-triggered apoptosis enforces minimal length of mitosis
in Nature volume 580 (2020) . - page 542-547
doi:10.1038/s41586-020-2187-y ...
2019
Henschke, Lars; Frese, Matthias; Hellmuth, Susanne; Marx, Andreas; Stemmann, Olaf; Mayer, Thomas U.
Identification of Bioactive Small Molecule Inhibitors of Separase
in ACS Chemical Biology volume 14 (2019) issue 10. - page 2155-2159
doi:10.1021/acschembio.9b00661 ...
2018
Wild, Thomas; Budzowska, Magda; Hellmuth, Susanne; Eibes, Susana; Karemore, Gopal; Barisic, Marin; Stemmann, Olaf; Choudhary, Chunaram
Deletion of APC7 or APC16 Allows Proliferation of Human Cells without the Spindle Assembly Chec ...
in Cell Reports volume 25 (2018) issue 9. - page 2317-2328
doi:10.1016/j.celrep.2018.10.104 ...
Hellmuth, Susanne; Gutiérrez-Caballero, Cristina; Llano, Elena; Pendás, Alberto M.; Stemmann, Olaf
Local activation of mammalian separase in interphase promotes double-strand break repair and pr ...
in The EMBO Journal volume 37 (2018) issue 22
doi:10.15252/embj.201899184 ...
Wolf, Peter G.; Ramos, Alexander Cuba; Kenzel, Julia; Neumann, Brigitte; Stemmann, Olaf
Studying meiotic cohesin in somatic cells reveals that Rec8-containing cohesin requires Stag3 t ...
in Journal of Cell Science volume 131 (2018) issue 11
doi:10.1242/jcs.212100 ...
2017
Ferencz, Csilla Maria; Guigas, Gernot; Veres, Andreas; Neumann, Brigitte; Stemmann, Olaf; Weiss, Matthias
In Vitro Reconstitution of the Endoplasmic Reticulum
in Current Protocols in Cell Biology volume 76 (2017)
doi:10.1002/cpcb.30 ...
2016
Ferencz, Csilla Maria; Guigas, Gernot; Veres, Andreas; Neumann, Brigitte; Stemmann, Olaf; Weiss, Matthias
Shaping the endoplasmic reticulum in vitro
in Biochimica et Biophysica Acta : Biomembranes volume 1858 (2016) issue 9. - page 2035-2040
doi:10.1016/j.bbamem.2016.06.004 ...
2015
Mohr, Lisa; Buheitel, Johannes; Schöckel, Laura; Karalus, Dorothea; Mayer, Bernd; Stemmann, Olaf
An Alternatively Spliced Bifunctional Localization Signal Reprograms Human Shugoshin 1 to Prote ...
in Cell Reports volume 12 (2015) issue 12. - page 2156-2168
doi:10.1016/j.celrep.2015.08.045 ...
Hellmuth, Susanne; Rata, Scott; Brown, Andreas; Heidmann, Stefan; Novak, Bela; Stemmann, Olaf
Human Chromosome Segregation Involves Multi-Layered Regulation of Separase by the Peptidyl-Prol ...
in Molecular Cell volume 58 (2015) issue 3. - page 495-506
doi:10.1016/j.molcel.2015.03.025 ...
Hellmuth, Susanne; Pöhlmann, Christopher; Brown, Andreas; Böttger, Franziska; Sprinzl, Mathias; Stemmann, Olaf
Positive and Negative Regulation of Vertebrate Separase by Cdk1-Cyclin B1 May Explain Why Secur ...
in The Journal of Biological Chemistry volume 290 (2015) issue 12. - page 8002-8010
doi:10.1074/jbc.M114.615310 ...
2014
Hellmuth, Susanne; Böttger, Franziska; Pan, Cuiping; Mann, Matthias; Stemmann, Olaf
PP2A delays APC/C-dependent degradation of separase-associated but not free securin
in The EMBO Journal volume 33 (2014) issue 10. - page 1134-1147
doi:10.1002/embj.201488098 ...
2013
Rattani, Ahmed; Wolna, Magda; Ploquin, Mickael; Helmhart, Wolfgang; Morrone, Seamus; Mayer, Bernd; Godwin, Jonathan; Xu, Wenqing; Stemmann, Olaf; Pendás, Alberto M.; Nasmyth, Kim
Sgol2 provides a regulatory platform that coordinates essential cell cycle processes during mei ...
in eLife volume 2 (2013)
doi:10.7554/eLife.01133.001 ...
Buheitel, Johannes; Stemmann, Olaf
Prophase pathway-dependent removal of cohesin from human chromosomes requires opening of the Sm ...
in The EMBO Journal volume 32 (2013) issue 5. - page 666-676
doi:10.1038/emboj.2013.7 ...
2012
Touati, Sandra A.; Cladière, Damien; Lister, Lisa M.; Leontiou, Ioanna; Chambon, Jean-Philippe; Rattani, Ahmed; Böttger, Franziska; Stemmann, Olaf; Nasmyth, Kim; Herbert, Mary; Wassermann, Katja
Cyclin A2 Is Required for Sister Chromatid Segregation, But Not Separase Control, in Mouse Oocy ...
in Cell Reports volume 2 (2012) issue 5. - page 1077-1087
doi:10.1016/j.celrep.2012.10.002 ...
2011
Franz, André; Orth, Michael; Pirson, Paul A.; Sonneville, Remi; Blow, J. Julian; Gartner, Anton; Stemmann, Olaf; Hoppe, Thorsten
CDC-48/p97 Coordinates CDT1 Degradation with GINS Chromatin Dissociation to Ensure Faithful DNA ...
in Molecular Cell volume 44 (2011) issue 1. - page 85-96
doi:10.1016/j.molcel.2011.08.028 ...
Schöckel, Laura; Möckel, Martin; Mayer, Bernd; Boos, Dominik; Stemmann, Olaf
Cleavage of cohesin rings coordinates the separation of centrioles and chromatids
in Nature Cell Biology volume 13 (2011) . - page 966-972
doi:10.1038/ncb2280 ...
Hormanseder, Eva; Tischer, Thomas; Heubes, Simone; Stemmann, Olaf; Mayer, Thomas U.
Non-proteolytic ubiquitylation counteracts the APC/C-inhibitory function of XErp1
in EMBO Reports volume 12 (2011) issue 5. - page 436-443
doi:10.1038/embor.2011.32 ...
Orth, Michael; Mayer, Bernd; Rehm, Kinga; Rothweiler, Ulli; Heidmann, Doris; Holak, Tad A.; Stemmann, Olaf
Shugoshin is a Mad1/Cdc20-like interactor of Mad2
in The EMBO Journal volume 30 (2011) . - page 2868-2880
doi:10.1038/emboj.2011.187 ...
2010
Wang, Lily Hui-Ching; Mayer, Bernd; Stemmann, Olaf; Nigg, Erich A.
Centromere DNA decatenation depends on cohesin removal and is required for mammalian cell divis ...
in Journal of Cell Science volume 123 (2010) issue 5. - page 806-813
doi:10.1242/jcs.058255 ...
2009
Kudo, Nobuaki R.; Anger, Martin; Peters, Antoine H.; Stemmann, Olaf; Theussl, Hans-Christian; Helmhart, Wolfgang; Kudo, Hiromi; Heyting, Christa; Nasmyth, Kim
Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I
in Journal of Cell Science volume 122 (2009) issue 15. - page 2686-2698
doi:10.1242/jcs.035287 ...
2008
Daub, Henrik; Olsen, Jesper V.; Bairlein, Michaela; Gnad, Florian; Oppermann, Felix S.; Korner, Roman; Greff, Zoltán; Keri, György; Stemmann, Olaf; Mann, Matthias
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cel ...
in Molecular Cell volume 31 (2008) issue 3. - page 438-448
doi:10.1016/j.molcel.2008.07.007 ...
Rothweiler, Ulli; Czarna, Anna; Weber, Lutz; Popowicz, Grzegorz M.; Brongel, Kinga; Kowalska, Kaja; Orth, Michael; Stemmann, Olaf; Holak, Tad A.
NMR screening for lead compounds using tryptophan-mutated proteins.
in Journal of Medicinal Chemistry volume 51 (2008) issue 16. - page 5035-5042
doi:10.1021/jm8002813 ...
Boos, Dominik; Kuffer, Christian; Lenobel, Rene; Korner, Roman; Stemmann, Olaf
Phosphorylation-dependent binding of cyclin B1 to a Cdc6-like domain of human separase
in The Journal of Biological Chemistry volume 283 (2008) issue 2. - page 816-823
doi:10.1074/jbc.M706748200 ...
Nabti, Ibtissem; Reis, Alexandra; Levasseur, Mark; Stemmann, Olaf; Jones, Keith T.
Securin and not CDK1/cyclin B1 regulates sister chromatid disjunction during meiosis II in mous ...
in Developmental Biology volume 321 (2008) issue 2. - page 379-386
doi:10.1016/j.ydbio.2008.06.036 ...
2007
Heubes, Simone; Stemmann, Olaf
The AAA-ATPase p97Ufd1/Npl4 Is Required for ERAD but Not for Spindle Disassembly in Xenopus Egg ...
in Journal of Cell Science volume 120 (2007) issue 8. - page 1325-1329
doi:10.1242/jcs.006924 ...
Holland, Andrew J.; Böttger, Franziska; Stemmann, Olaf; Taylor, Stephen S.
Protein phosphatase 2A and separase form a complex regulated by separase autocleavage
in The Journal of Biological Chemistry volume 282 (2007) issue 34. - page 24623-24632
doi:10.1074/jbc.M702545200 ...
2006
Gorr, Ingo H.; Reis, Alexandra; Boos, Dominik; Wühr, Martin; Madgwick, Suzanne; Jones, Keith T.; Stemmann, Olaf
Essential Cdk1-inhibitory role for separase during meiosis I in vertebrate oocytes
in Nature Cell Biology volume 8 (2006) . - page 1035-1037
doi:10.1038/ncb1467 ...
Stemmann, Olaf; Boos, Dominik; Gorr, Ingo H.
Anaphase Topsy-Turvy : Cdk1 a securin, separase a CKI
in Cell Cycle volume 5 (2006) issue 1. - page 11-13
doi:10.4161/cc.5.1.2296 ...
2005
Gorr, Ingo H.; Boos, Dominik; Stemmann, Olaf
Mutual Inhibition of Separase and Cdk1 by Two-Step Complex Formation
in Molecular Cell volume 19 (2005) issue 1. - page 135-141
doi:10.1016/j.molcel.2005.05.022 ...
Viadiu, Hector; Stemmann, Olaf; Kirschner, Marc W.; Walz, Thomas
Domain structure of separase and its binding to securin as determined by EM
in Nature Structural & Molecular Biology volume 12 (2005) . - page 552-553
doi:10.1038/nsmb935 ...
Stemmann, Olaf; Boos, Dominik; Gorr, Ingo H.
Rephrasing anaphase : Separase FEARs shugoshin
in Chromosoma volume 113 (2005) issue 8. - page 409-417
doi:10.1007/s00412-005-0331-y ...
Pfleghaar, Katrin; Heubes, Simone; Cox, Jürgen; Stemmann, Olaf; Speicher, Michael R.
Securin Is Not Required for Chromosomal Stability in Human Cells
in PLoS Biology volume 3 (2005) issue 12
doi:10.1371/journal.pbio.0030416 ...
2003
Gerber, Scott A.; Rusch, John; Stemmann, Olaf; Kirschner, Marc W.; Gygi, Steven P.
Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS
in Proceedings of the National Academy of Sciences of the United States of America volume 100 (2003) issue 12. - page 6940-6945
doi:10.1073/pnas.0832254100 ...
2002
Zou, Hui; Stemmann, Olaf; Anderson, Jens S.; Mann, Matthias; Kirschner, Marc W.
Anaphase specific auto-cleavage of separase
in FEBS Letters volume 528 (2002) issue 1-3. - page 246-250
doi:10.1016/S0014-5793(02)03238-6 ...
Stemmann, Olaf; Neidig, Anke; Köcher, Thomas; Wilm, Matthias; Lechner, Johannes
Hsp90 enables Ctf13p/Skp1p to nucleate the budding yeast kinetochore
in Proceedings of the National Academy of Sciences of the United States of America volume 99 (2002) issue 13. - page 8585-8590
doi:10.1073/pnas.082223899 ...
2001
Stemmann, Olaf; Zou, Hui; Gerber, Scott A.; Gygi, Steven P.; Kirschner, Marc W.
Dual inhibition of sister chromatid separation at metaphase
in Cell volume 107 (2001) issue 6. - page 715-726
doi:10.1016/S0092-8674(01)00603-1 ...
1999
Pietrasanta, Lía I.; Thrower, Douglas; Hsieh, Wan; Rao, Shashirekha; Stemmann, Olaf; Lechner, Johannes; Carbon, John; Hansma, Helen
Probing the Saccharomyces cerevisiae centromeric DNA (CEN DNA)-binding factor 3 (CBF3) kinetoch ...
in Proceedings of the National Academy of Sciences of the United States of America volume 96 (1999) issue 7. - page 3757-3762
doi:10.1073/pnas.96.7.3757 ...
Ortiz, Jennifer; Stemmann, Olaf; Rank, Simone; Lechner, Johannes
A putative protein complex consisting of Ctf19, Mcm21, and Okp1 represents a missing link in th ...
in Genes & Development volume 13 (1999) . - page 1140-1155
http://www.ncbi.nlm.nih.gov/pubmed/10323865?ordina ...
1996
Brikun, I.; Suziedelis, K.; Stemmann, Olaf; Zhong, R.; Alikhanian, L.; Linkova, E.; Mironov, A.; Berg, D. E.
Analysis of CRP-CytR interactions at the Escherichia coli udp promoter
in Journal of Bacteriology volume 178 (1996) issue 6. - page 1614-1622
http://www.ncbi.nlm.nih.gov/pubmed/8626289?ordinal ...
Stemmann, Olaf; Lechner, Johannes
The Saccharomyces cerevisiae kinetochore contains a cyclin-CDK complexing homologue, as identif ...
in The EMBO Journal volume 15 (1996) issue 14. - page 3611-3620
http://www.ncbi.nlm.nih.gov/pubmed/8670864?ordinal ...
Biology, Chemistry & Earth Sciences
Chair of Genetics
Prof. Dr. Olaf Stemmann
Principal Investigator
Phone: +49 (0)921 / 55-2701
E-mail: olaf.stemmann@uni-bayreuth.de
Google Scholar: Link
ORCID: Link